Anti-PRKCDBP (Cavin-3) Rabbit Polyclonal Antibody for WB, ELISA - Q969G5

Core Product Specifications and Parameters

Biological Background: PRKCDBP Function and Localization

• PRKCDBP, also known as cavin-3 or SRBC, is a caveolae-associated protein that functions as a tumor suppressor and regulator of caveolae dynamics.
• It regulates the traffic and budding of caveolae, influencing the equilibrium between cell surface-associated and dissociated caveolae by promoting rapid release from the cell surface. Related references: PMID:19262564
• Plays a tissue-specific role in caveola formation: required in smooth muscle but not in lung and heart endothelial cells.
• Involved in the regulation of the circadian clock, modulating period length and phase of circadian gene expression, and interacting with core clock components PER1/2 and CRY1/2.
• Localized to the cytoplasm, membrane, caveola, and cytosol.
• Post-translationally modified by phosphorylation and ubiquitination (isopeptide bond and Ubl conjugation), likely regulating its function.
• Highly expressed in skeletal muscle, liver, stomach, lung, kidney, heart, and strongly in mammary and epithelial cells.

Experimental Guidance and Technical Tips

• For Western blot, the predicted molecular weight is 28 kDa; appropriate loading controls should be used.
• Given the polyclonal nature, it may detect multiple bands; validate specificity in your sample system.
• For ELISA, consider using recombinant protein as standard.
• Cross-reactivity with rat has been demonstrated; other species should be tested individually.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to high-quality IVD raw materials, including validated antibodies like this anti-PRKCDBP rabbit polyclonal antibody. Whether you need bulk ancillary reagents, optimized antibody pairs, or rare target sourcing for caveolae biology and circadian rhythm studies, CamelBio supports your project from concept to clinic.