Anti-PRELP Polyclonal Antibody for WB and ELISA - P51888

Core Product Specifications and Parameters

Biological Background: Prolargin Function and Localization

• Prolargin (PRELP) is a proline-arginine-rich end leucine-rich repeat protein, also known as SLRR2A, belonging to the small leucine-rich proteoglycan (SLRP) family. It is encoded by the PRELP gene in humans.
• PRELP functions to anchor basement membranes to the underlying connective tissue, playing a structural role in the extracellular matrix.
• The protein is secreted and localizes to the extracellular space and extracellular matrix, consistent with its role in matrix organization.
• PRELP is predominantly expressed in connective tissues, highlighting its specialized function in tissue architecture.
• As a proteoglycan, PRELP contains heparan sulfate chains and exhibits heparin-binding properties, which may contribute to its interactions with other matrix components.
• It features leucine-rich repeats, a hallmark of the SLRP family, and includes disulfide bonds that stabilize its structure.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a recombinant fragment spanning amino acids 200-360 of human PRELP. This region may cover functionally relevant leucine-rich repeat motifs; consider this when interpreting binding specificity.
• For Western blotting, the antibody detects a band at approximately 44 kDa, consistent with the reported molecular weight; validate in positive samples such as connective tissue lysates.
• This polyclonal antibody is suitable for ELISA applications; consider pairing it with a matched detection antibody if used in sandwich assays.
• Cross-reactivity with mouse and rat is confirmed; however, titrate individually for each species to optimize signal-to-noise ratios.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive access to IVD raw materials, including this PRELP polyclonal antibody for extracellular matrix and basement membrane research. As a trusted sourcing partner for diagnostic manufacturers and laboratories, CamelBio can supply validated antibody pairs, bulk ancillary reagents, and specialized raw materials to streamline your assay development. Whether you need optimized monoclonal antibodies or rare-target sourcing, CamelBio bridges the gap from concept to clinical application.