Anti-PRDM11 Polyclonal Antibody for WB, ELISA - Q9NQV5

Core Product Specifications and Parameters

Biological Background: PRDM11 Function and Localization

• PRDM11 (also known as PFM8) is a PR domain-containing protein encoded by the PRDM11 gene.
• It is proposed to be involved in transcriptional regulation.
• The protein localizes to both the nucleus and the cytoplasm.
• PRDM11 is highly expressed in the lung, including in bronchial epithelial cells and airway smooth muscle cells, as well as in peripheral blood mononuclear cells.
• In lymphoid tissues, it is detected in various B-cell developmental stages, including naive B-cells, centroblasts, centrocytes, and memory B-cells.
• Keyword annotations classify PRDM11 as a methyltransferase and transferase, suggesting enzymatic activity that may involve S-adenosyl-L-methionine.
• The protein undergoes post-translational modifications such as phosphorylation and ubiquitin-like conjugation (isopeptide bond formation).

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 228–477 of human PRDM11; the antibody may recognize both full-length and potential isoforms.
• In Western blotting, a band near 58 kDa is expected; however, alternative splicing or post-translational modifications could lead to size shifts—validate in your specific sample system.
• Cross-reactivity with mouse is reported; for mouse models, confirm detection efficiency and specificity under your experimental conditions.
• For ELISA applications, the recombinant immunogen can be utilized as a positive control to optimize assay conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves diagnostic manufacturers and research institutes as a comprehensive source for IVD raw materials, offering validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents. For transcription regulation and epigenetic research, our catalog includes antibodies targeting PRDM11 and related factors. Backed by a robust supply network, we also support the sourcing of rare-target raw materials, helping to accelerate your project from concept to clinical application.