Anti-POLDIP2 Rabbit Polyclonal Antibody for WB and ELISA - Q9Y2S7

Core Product Specifications and Parameters

Biological Background: POLDIP2 Function and Localization

• Polymerase delta-interacting protein 2 (POLDIP2), also known as p38, is involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025).
  Related references: PMID:24191025
• POLDIP2 may stimulate the activity of DNA polymerases involved in TLS, including PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527).
  Related references: PMID:24191025 PMID:26984527
• The protein localizes to the mitochondrial matrix and the nucleus, consistent with roles in genomic and mitochondrial DNA maintenance.
• It is classified under keywords including DNA damage, DNA repair, mitochondrion, nucleus, phosphoprotein, and reference proteome.
• The full-length protein has a predicted molecular weight of approximately 42 kDa (UniProt).
• No known alternative isoforms have been described.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a synthetic peptide spanning residues 250–350 of human POLDIP2; conservation across species is consistent with the reported cross-reactivity to mouse and rat.
• For WB, expect a band near 42 kDa; use appropriate positive control lysates from human, mouse, or rat cells.
• For ELISA, the immunogen peptide or recombinant POLDIP2 protein can serve as positive controls to assess reactivity.
• As a polyclonal antibody, validate specificity in the relevant sample system and consider blocking peptides to confirm target recognition.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop sourcing solution for IVD raw materials, including this anti-POLDIP2 polyclonal antibody, supporting research in DNA damage and repair. Our portfolio encompasses validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets—streamlining your workflow from development to diagnostic application.