Anti-PMS1 Rabbit Polyclonal Antibody for WB and ELISA - P54277

Core Product Specifications and Parameters

Biological Background: PMS1 Function and Localization

• PMS1 (PMS1 protein homolog 1), also known as DNA mismatch repair protein PMS1, is encoded by the PMS1 gene.
• It is probably involved in the repair of DNA mismatches, contributing to genome stability.
• PMS1 localizes to the nucleus, consistent with its role in DNA repair processes.
• The protein is implicated in hereditary nonpolyposis colorectal cancer (HNPCC) and acts as a tumor suppressor.
• Key functional keywords include DNA damage, DNA repair, DNA-binding, alternative splicing, and 3D-structure.
• PMS1 is a member of the MutL family of DNA mismatch repair proteins.

Experimental Guidance and Technical Tips

• For Western blotting, expect a band around 106 kDa; consider using positive and negative control lysates to validate specificity.
• Since PMS1 undergoes alternative splicing, multiple isoforms may be detected; confirm the identity of bands in your sample system.
• As a polyclonal antibody, it may recognize multiple epitopes; include appropriate blocking and washing steps to minimize non-specific signals.
• The immunogen spans amino acids 405–619, which is conserved in mouse and rat; cross-reactivity is expected, but validate in those species if used.
• For ELISA, optimize coating conditions and antibody dilutions for your specific assay format.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio partners with diagnostic manufacturers and research teams to supply premium IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For projects focused on DNA repair or cancer biomarker development, we offer reliable PMS1 antibody sourcing and can assist with rare-target raw-material procurement. Reach out to discuss how we can support your end-to-end development—from concept to clinic.