Anti-PMP70/ABCD3 Rabbit Polyclonal Antibody - P28288

Core Product Specifications and Parameters

Biological Background: PMP70/ABCD3 Function and Localization

• PMP70/ABCD3 (ATP-binding cassette sub-family D member 3) is a 75 kDa peroxisomal membrane protein belonging to the ABC transporter family, encoded by the ABCD3 gene in humans.
• It functions as a broad-specificity ATP-dependent transporter that imports long-chain fatty acyl-CoAs, dicarboxylic acids, branched-chain fatty acids, and bile acids into the peroxisome for β-oxidation. Related references: PMID:11248239, PMID:24333844, PMID:25168382
• The protein also possesses fatty acyl-CoA thioesterase and ATPase activities, contributing to its role in fatty acid metabolism. Related references: PMID:29397936
• PMP70/ABCD3 plays a critical role in fatty acid degradation and biosynthesis, thereby impacting energy homeostasis. Related references: PMID:24333844, PMID:25944712
• Subcellular localization is strictly at the peroxisome membrane, consistent with its function in peroxisomal import.
• Post-translational modifications include acetylation and phosphorylation; it is also predicted to be glycosylated and to undergo ubiquitination.
• Alternative splicing generates multiple isoforms, potentially expanding functional diversity.
• The protein is also known as ZWS2, ABC43, CBAS5, PMP70, and PXMP1 in historical literature.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 340–475, a region that may influence detection of specific conformations or interaction states; consider this when interpreting results.
• For Western blotting, the predicted molecular weight is ~75 kDa; include appropriate size markers and optimize blocking conditions to reduce non-specific binding.
• In immunofluorescence or immunohistochemistry, expect punctate peroxisomal staining; co-stain with organelle markers to confirm localization.
• This antibody has been evaluated in ELISA; it may be suitable for high-throughput screening or quantitative assays after in-house validation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For researchers investigating peroxisomal biology and metabolic disorders, we provide reliable access to PMP70/ABCD3 detection tools and can source rare-target raw materials to accelerate your assay development. Our supply chain expertise bridges the gap from concept to clinic, ensuring seamless procurement of high-quality reagents.