Anti-PLIN5 Polyclonal Antibody for WB, ELISA - Q00G26

Core Product Specifications and Parameters

Biological Background: PLIN5 Function and Localization

• Perilipin-5 (PLIN5), also known as lipid storage droplet protein 5 (LSDP5), MLDP, LSDA5, and OXPAT, is a member of the perilipin family of lipid droplet-associated proteins.
• Functions to maintain the balance between lipogenesis and lipolysis, and regulates fatty acid oxidation in oxidative tissues by recruiting mitochondria to lipid droplet surfaces.
• Acts as a scaffolding protein for key lipolytic regulators ABHD5, PNPLA2, and LIPE, modulating triacylglycerol hydrolysis and fatty acid release.
• Reduces PNPLA2 activity by sequestering it at lipid droplets; phosphorylation by PKA promotes lipolysis by enabling ABHD5 release and interaction with PNPLA2 and LIPE.
• Localizes to lipid droplets, cytoplasm, and mitochondria.
• Expressed in skeletal muscle, liver, heart, and kidney.
• Classified as a phosphoprotein involved in lipid metabolism, with proteomics identification confirmed.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide spanning amino acids 302-401 of human PLIN5; consider this region for epitope mapping and peptide-based ELISA competition assays.
• For Western blot, the predicted molecular weight is 51 kDa; validate band detection in relevant tissue lysates (skeletal muscle, liver, heart) where PLIN5 expression is reported.
• Cross-reactivity with mouse and rat PLIN5 is indicated; verify suitability in your orthologous sample system.
• ELISA applications may utilize the peptide immunogen as coating antigen; users should optimize coating conditions and detection parameters.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive sourcing solution for diagnostic and research raw materials, including validated polyclonal antibodies like this anti-PLIN5 product, ideal for studying lipid droplet biology and metabolic disorders. We specialize in supplying optimized antibody pairs, bulk ancillary reagents, and facilitating access to rare-target reagents—supporting your workflow from discovery to clinical application with reliable, high-quality materials.