Anti-PLCXD2 Rabbit Polyclonal Antibody for WB, ELISA - Q0VAA5

Core Product Specifications and Parameters

Biological Background: PLCXD2 Function and Localization

• PLCXD2 (Phospholipase C X-domain containing protein 2) is a member of the phospholipase C family that hydrolyzes phosphatidylinositol (PI) and potentially its multi-phosphorylated derivatives like PIP2, generating second messengers IP3 and DAG (PubMed:22732399). Related references: PMID:22732399
• PLCXD2 is encoded by the PLCXD2 gene (Gene ID: 257068) and produces a protein with a predicted molecular weight of ~35 kDa; alternative splicing generates multiple isoforms.
• Subcellularly, PLCXD2 localizes predominantly to the nucleus, suggesting a role in nuclear lipid signaling and gene regulation.
• The protein is widely expressed across tissues, indicating a fundamental housekeeping function in cellular signaling pathways.
• PLCXD2 is classified as a hydrolase involved in lipid degradation and metabolism, and it may function as a signal transducer linking extracellular cues to intracellular responses.
• It is a reference proteome member, identified through high-throughput proteomics, underscoring its documented existence and characterization.

Experimental Guidance and Technical Tips

• When performing Western blotting, consider using whole-cell or nuclear extracts given PLCXD2's nuclear localization; a band around 35 kDa is expected.
• For ELISA, the antibody may be used for direct or indirect detection; optimization of coating antigen and antibody concentration is recommended.
• As a polyclonal antibody, it may recognize multiple isoforms or post-translationally modified forms; validate specificity in your experimental system.
• Due to cross-reactivity with mouse and rat, this antibody is suitable for studies in rodent models; however, verify performance in each species' tissue.
• The immunogen corresponds to the N-terminal region (aa 1-305); consider the potential presence of splice variants that may affect recognition.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, providing validated antibody pairs, bulk ancillary reagents, and tailored procurement solutions. This anti-PLCXD2 antibody supports research into lipid signaling and nuclear function, areas where CamelBio offers complementary reagents and deep technical support. Our one-stop platform streamlines the journey from discovery to diagnostic application, ensuring reliable supply chains for critical targets.