Anti-Placental lactogen (CSH1) Polyclonal Antibody for IHC-P, ELISA - P0DML2

Core Product Specifications and Parameters

Biological Background: Placental lactogen (CSH1) Function and Localization

• Chorionic somatomammotropin hormone 1 (CSH1), also known as placental lactogen (PL), is a pregnancy-specific hormone member of the growth hormone/prolactin family.
• It is produced exclusively during pregnancy and plays a key role in stimulating lactation, fetal growth, and maternal metabolism.
• CSH1 signals exclusively through the prolactin receptor (PRLR) via zinc-induced dimerization, with no interaction with the growth hormone receptor (GHR).
• The protein is secreted and contains a signal peptide, disulfide bonds, and a zinc-binding site, indicative of its hormonal function.
• Post-translational modifications and structural features include disulfide bond formation and metal-binding, crucial for receptor activation.
• UniProt keywords classify CSH1 as a hormone, secreted, with a reference proteome, and supported by direct protein sequencing evidence.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 27–217 of the mature protein, excluding the signal peptide; this design may favor detection of the processed, secreted form.
• For immunohistochemistry on paraffin-embedded tissues (IHC-P), consider antigen retrieval protocols optimized for placental sections and validate with appropriate positive and negative controls.
• In ELISA applications, the antibody may be used as a capture or detection reagent; confirm optimal working dilution and pairing with relevant standards in the user's experimental system.
• Cross-reactivity is reported for human samples; for other species, verify sequence homology before use.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with consolidated access to a broad portfolio of IVD raw materials, including validated antibody pairs, bulk monoclonal and polyclonal antibodies, and ancillary reagents. This anti-Placental lactogen (CSH1) polyclonal antibody supports pregnancy and reproductive biology research. For rare-target or custom raw-material sourcing needs, our technical team offers tailored supply solutions.