Anti-Pin1 Rabbit Polyclonal Antibody - Q13526

Core Product Specifications and Parameters

Biological Background: Pin1 Function and Localization

• Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is a PPIase that specifically isomerizes phosphorylated Ser/Thr-Pro motifs, acting as a molecular switch in multiple cellular processes. Related references: PMID:21497122, PMID:23623683, PMID:29686383
• Regulates mitosis by interacting with NIMA and attenuating its mitosis-promoting activity; also down-regulates BTK kinase activity. Related references: PMID:16644721
• Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability, and cell transformation.
• Required for efficient dephosphorylation and recycling of RAF1 after mitogen activation; also targets PML and BCL6 for phosphorylation-dependent degradation. Related references: PMID:15664191, PMID:17828269
• Acts as a regulator of the JNK cascade by binding phosphorylated FBXW7, promoting its autoubiquitination and degradation, thereby stabilizing JUN. Related references: PMID:22608923
• May facilitate RBBP8/CtIP ubiquitination and degradation, favoring error-prone NHEJ over error-free HR. Related references: PMID:23623683, PMID:27561354
• Catalyzes isomerization of phosphorylated IRAK3 and PGK1, modulating inflammation and mitochondrial targeting under hypoxia. Related references: PMID:29686383, PMID:26942675
• Localizes to the nucleus, nuclear speckles, and cytoplasm; expressed in immune cells in the lung; the phosphorylated form at Ser-71 is found in normal breast tissue but not breast cancer cells.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1-163 of human Pin1; consider verifying reactivity in your specific sample matrix.
• This antibody is validated for WB and ELISA; for other applications, optimization and validation are recommended.
• Known cross-reactivity with mouse and rat suggests potential use in these species; confirm with pilot experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your trusted partner for IVD raw-material sourcing, offering validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to support your assay development. This Pin1 antibody is part of our cell cycle and oncology research portfolio, providing a reliable reagent for diagnostic manufacturers and research laboratories. Leverage our supply capabilities for rare-target raw materials and accelerate your project from concept to clinic.