Anti-Phospholipid Scramblase 1 (PLSCR1) Polyclonal Antibody for WB and ELISA - O15162

Core Product Specifications and Parameters

Biological Background: Phospholipid Scramblase 1 Function and Localization

• Phospholipid scramblase 1 (PLSCR1) catalyzes calcium-induced ATP-independent bidirectional phospholipid translocation (scrambling) across the plasma membrane, leading to phosphatidylserine externalization during apoptosis and platelet activation. Related references: PMID:10770950 PMID:18629440 PMID:23590222
• PLSCR1 exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA, and enhances DNA decatenation mediated by TOP2A. Related references: PMID:17567603 PMID:27206388
• It negatively regulates FcR-mediated phagocytosis in differentiated macrophages. Related references: PMID:26745724
• PLSCR1 amplifies the interferon antiviral response and directly inhibits viral transactivators from HTLV-1, HIV-1, HBV, EBV, and HCMV. Related references: PMID:15308695 PMID:22789739 PMID:23501106 PMID:25365352
• It inhibits influenza virus infection by blocking nuclear import of viral nucleoprotein. Related references: PMID:29352288 PMID:35595813
• PLSCR1 serves as a defense factor against SARS-CoV-2 by preventing virus-membrane fusion and viral RNA release. Related references: PMID:37438530
• Acts as an attachment receptor for hepatitis C virus (HCV) entry.
• Expressed in many tissues including platelets, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney, and pancreas; not detected in brain and skeletal muscle. Subcellularly localized at the cell membrane, nucleus, cytoplasm, and perinuclear region. Post-translational modifications include phosphorylation and palmitoylation.

Experimental Guidance and Technical Tips

• For Western blotting, the predicted molecular weight is 35 kDa; however, post-translational modifications or isoforms may result in additional bands.
• The immunogen spans amino acids 1–318, representing the full-length protein. Consider the possibility of detecting alternative splice variants or modified forms.
• Validate the antibody in relevant cell lines reported to express PLSCR1, such as HeLa or Jurkat cells, using appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, laboratories, and research institutes a streamlined pathway to high-quality IVD raw materials, including validated antibodies like this anti-PLSCR1 polyclonal antibody. Our supply capabilities encompass optimized polyclonal and monoclonal antibodies, validated antibody pairs, bulk ancillary reagents, and specialized sourcing for rare or emerging targets in apoptosis, antiviral defense, and membrane biology. Partner with us to accelerate your assay development from concept to clinic.