Anti-PGM2 Rabbit Polyclonal Antibody for WB, ELISA - Q96G03

Core Product Specifications and Parameters

Biological Background: PGM2 Function and Localization

• Phosphopentomutase (PGM2), also known as glucose phosphomutase 2, phosphodeoxyribomutase, and phosphoglucomutase-2, is encoded by the PGM2 gene in humans.
• Functions as a phosphopentomutase that catalyzes the interconversion of ribose-1-phosphate and deoxyribose-1-phosphate to their corresponding 5-phosphopentoses, playing a key role in nucleotide salvage pathways. Related references: PMID:17804405
• Also exhibits phosphoglucomutase activity, reversibly isomerizing α-D-glucose 1-phosphate to α-D-glucose 6-phosphate, albeit with lower catalytic efficiency, via an α-D-glucose 1,6-bisphosphate intermediate. Related references: PMID:17804405
• Possesses weak glucose 1,6-bisphosphate synthase activity in vitro, though this is unlikely to be physiologically relevant. Related references: PMID:17804405, PMID:18927083
• Primarily localized to the cytoplasm and cytosol.
• Subject to post-translational modifications including acetylation and phosphorylation; requires magnesium as a cofactor.
• Alternatively spliced variants have been reported.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1-130) of human PGM2, which may be suitable for detecting full-length and N-terminal isoforms.
• For Western blotting, consider using whole-cell lysates from human or mouse tissues/cell lines expressing PGM2; the theoretical molecular weight is approximately 68 kDa.
• For ELISA applications, validate with recombinant PGM2 protein or peptide to ensure specificity and sensitivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a trusted one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. Our PGM2 Rabbit pAb supports research into nucleotide and glucose metabolism, facilitating assay development. We also specialize in rare target raw-material sourcing and technical consulting to streamline your development from concept to clinic.