Anti-PEX3 Polyclonal Antibody for WB, ELISA - P56589

Core Product Specifications and Parameters

Biological Background: PEX3 Function and Localization

• PEX3 (Peroxisomal biogenesis factor 3), also known as Peroxin-3 or Peroxisomal assembly protein PEX3, is encoded by the PEX3 gene (GeneID: 8504).
• It plays a critical role in peroxisome biosynthesis and integrity by assembling membrane vesicles before matrix protein translocation.
• PEX3 serves as a docking factor for PEX19, facilitating the import of peroxisomal membrane proteins into the peroxisome.
• The protein localizes specifically to the peroxisome membrane and is a multi-pass transmembrane protein.
• Mutations in PEX3 are linked to peroxisome biogenesis disorders such as Zellweger syndrome spectrum (PBD10A, PBD10B).
• PEX3 is ubiquitously expressed across all examined tissues, underscoring its essential housekeeping role.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 144–373) covers a significant cytoplasmic domain, which may improve accessibility in native conformations; consider using this antibody in WB under both denaturing and non-denaturing conditions.
• For Western blot, peroxisome-enriched subcellular fractions may enhance detection sensitivity; validate in the relevant species (human, mouse, rat).
• In ELISA applications, consider peptide competition assays to confirm specificity or use recombinant PEX3 protein as a positive control.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your integrated partner for IVD raw-material procurement, delivering validated antibodies, bulk ancillary reagents, and rare-target sourcing from concept to clinic. This anti-PEX3 antibody exemplifies our capability to supply critical tools for peroxisome biogenesis and related disorder research. Whether you need monoclonal pairs, custom recombinant proteins, or technical support, CamelBio streamlines your diagnostic development pipeline.