Anti-Perilipin-2 Polyclonal Antibody for WB, IF/ICC, IHC-P, ELISA - Q99541

Core Product Specifications and Parameters

Biological Background: Perilipin-2 Function and Localization

• Perilipin-2, also known as Adipophilin or adipose differentiation-related protein (ADRP), is encoded by the PLIN2 gene in humans.
• It functions as a structural component of lipid droplets, playing a critical role in the formation and maintenance of lipid storage organelles.
• Subcellularly, Perilipin-2 localizes to the membrane of lipid droplets and is detected in milk lipid globules.
• The protein undergoes post-translational modifications such as acetylation, phosphorylation, and ubiquitination, which may regulate its function and stability.
• As a member of the perilipin family, Perilipin-2 is involved in lipid metabolism and energy homeostasis.
• Its expression is conserved across mammalian species, with cross-reactivity observed in human, mouse, and rat.

Experimental Guidance and Technical Tips

• The immunogen for this antibody spans amino acids 168-437 of human Perilipin-2 (NP_001113.2), targeting a region critical for specific detection.
• For Western blot (WB), anticipate a band at approximately 48 kDa; use reducing conditions and validate with appropriate positive controls.
• In immunocytochemistry (ICC) and IHC, optimize fixation (e.g., 4% PFA) and permeabilization to preserve lipid droplet structures; consider a mild blocking step.
• When applying to mouse or rat samples, confirm cross-reactivity via pilot experiments, as sequence homology may vary.
• For ELISA, pair with a suitable capture antibody and standardized antigen for quantitative detection.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, including validated antibody pairs, monoclonal/polyclonal antibodies, and bulk ancillary reagents. This Perilipin-2 antibody supports research into lipid metabolism, obesity, and related disorders. With a global supply chain, CamelBio ensures efficient sourcing of rare-target raw materials and provides technical support from concept to clinic.