Anti-PEG10 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q86TG7

Core Product Specifications and Parameters

Biological Background: PEG10 Function and Localization

• PEG10 (Paternally Expressed Gene 10) is a retrotransposon-derived protein, also known as EDR, Mar2, RTL2, MEF3L, Mart2, RGAG3, and SIRH1. It is conserved across human, mouse, and rat.
• The protein binds its own mRNA and self-assembles into virion-like capsids, forming extracellular vesicles that mediate intercellular mRNA transfer. Related references: PMID:34413232
• PEG10 is essential for placental development, being required for trophoblast stem cell differentiation.
• Overexpressed in numerous cancers, PEG10 promotes cell proliferation by driving G0/G1 cell cycle progression. Related references: PMID:12810624, PMID:16423995, PMID:26235627
• The protein enhances tumor progression by inhibiting TGF-beta signaling, possibly through interaction with the receptor ACVRL1. Related references: PMID:15611116, PMID:26235627, PMID:30094509
• Subcellular localization includes the extracellular vesicle membrane, cytoplasm, and nucleus.
• Tissue specificity: detected in cytotrophoblast, prostate and breast carcinomas, Hep-G2 cells, and various normal tissues including brain, liver, kidney, and placenta.
• Keywords from UniProt: zinc-finger domains, DNA- and RNA-binding, coiled coil, apoptosis, and roles in differentiation and transport.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 1-325) covers the N-terminal region of PEG10, which may include key functional domains; consider epitope accessibility in your assay design.
• For Western blotting, a band around 80 kDa is expected; validate in PEG10-expressing samples such as Hep-G2 cells or placental tissue.
• In IHC-P, optimize antigen retrieval and confirm staining patterns in known positive (e.g., trophoblast, carcinoma) and negative tissues.
• Cross-reactivity with mouse and rat allows parallel studies in these species; verify specificity under your experimental conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research institutions a comprehensive one-stop sourcing platform for IVD raw materials, including validated antibodies, bulk ancillary reagents, and rare target procurement. This anti-PEG10 antibody supports investigations into cancer biology and developmental processes. From concept to clinic, our portfolio streamlines your entire development pipeline with reliable supply and technical support.