Anti-PDGFC Polyclonal Antibody for WB, ELISA - Q9NRA1

Core Product Specifications and Parameters

Biological Background: PDGFC Function and Localization

• PDGFC encodes platelet-derived growth factor C, also known as fallotein, spinal cord-derived growth factor (SCDGF), or VEGF-E.
• It is a growth factor essential for embryonic development, regulating cell proliferation, migration, survival, and chemotaxis, particularly of mesenchymal cells.
• PDGFC is critical for normal skeleton formation, craniofacial development, palate formation, and skin morphogenesis during embryogenesis.
• It plays key roles in wound healing (inflammation, proliferation, remodeling), angiogenesis, blood vessel development, and fibrotic processes.
• The protein contains a CUB domain with mitogenic activity in smooth muscle cells, suggesting functions beyond maintaining PDGF domain latency, and may have additional roles in the nucleus.
• Subcellular localization includes cytoplasm, cytosol, secreted forms, nucleus, cytoplasmic granules, and cell membrane.
• It is highly expressed in fallopian tube, vascular smooth muscle, kidney, breast, colon, retinal pigment epithelia, platelets, prostate, testis, and uterus; expression is elevated in uterine leiomyomata.
• Keywords: Alternative splicing, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Growth factor, Mitogen, Ubl conjugation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (aa 166-345) of human PDGFC, which includes the growth factor domain. The antibody may detect both full-length and cleaved forms.
• For Western blot, the predicted molecular weight is 39 kDa; however, post-translational modifications or cleavage may result in multiple bands. Validate in your target sample system.
• For ELISA, pair with a capture antibody if developing a sandwich assay, and optimize coating conditions using recombinant protein or native samples.
• Cross-reactivity with mouse and rat is reported; further validation is recommended for other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive one-stop sourcing solution for IVD raw materials, supporting diagnostic manufacturers and researchers from concept to clinic. For PDGFC-related research in developmental biology, angiogenesis, and fibrotic diseases, we provide validated polyclonal antibodies and can assist in sourcing matched antibody pairs, bulk reagents, and other ancillary materials to accelerate your assay development. Our supply network covers rare targets and custom production needs.