Anti-PAX2 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - Q02962

Core Product Specifications and Parameters

Biological Background: PAX2 Function and Localization

• Encodes the paired box protein Pax-2, a transcription factor critical for embryonic development of the urogenital tract, eyes, and central nervous system.
• Plays a key role in kidney cell differentiation (PubMed:24676634). Related references: PMID:24676634
• Localizes predominantly to the nucleus where it binds DNA to regulate gene expression.
• Member of the paired box (PAX) family of transcription factors characterized by a paired domain.
• Undergoes phosphorylation, as indicated by phosphoprotein keyword, suggesting regulation by post-translational modifications.
• Expressed in primitive cells of the kidney, ureter, eye, ear, and central nervous system during development.
• Involved in alternative splicing, generating isoforms that may have distinct functions.

Experimental Guidance and Technical Tips

• For Western blot, expect a band near 45 kDa; consider using kidney tissue lysates as a positive control and validate antibody specificity with blocking peptide if needed.
• In immunofluorescence/ICC, a nuclear staining pattern is anticipated; optimize fixation and permeabilization protocols for your cell type.
• This polyclonal antibody may exhibit lot-to-lot variability; preliminary titration experiments are recommended for each new batch.
• Cross-reactivity with mouse and rat makes it suitable for comparative studies, but sequence alignment of the immunogen region across species is advised to confirm epitope conservation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research labs with one-stop access to IVD raw materials, including validated anti-PAX2 antibodies for developmental biology and kidney disease studies. Beyond this polyclonal antibody, we supply optimized monoclonal antibodies, bulk ancillary reagents, and specialize in sourcing rare-target raw materials to accelerate your assay development. Let us be your reliable partner from concept to clinic.