Anti-PATZ1 Polyclonal Antibody for WB, ELISA - Q9HBE1

Core Product Specifications and Parameters

Biological Background: POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1) Function and Localization

• PATZ1 is a transcriptional regulator featuring a BTB/POZ domain, AT hook, and multiple C2H2-type zinc fingers. It participates in embryogenesis, senescence, T-cell development, and neurogenesis. Mechanistically, it interacts with TP53/p53 to control genes involved in proliferation and DNA-damage response by inhibiting p53's DNA binding and transcriptional activity. Related references: PMID:10713105 PMID:25755280 PMID:31875552
• During microbial infection, PATZ1 plays a positive role in viral cDNA synthesis.
• Subcellular localization is primarily nuclear.
• It is ubiquitously expressed across tissues.
• Post-translational modifications include phosphorylation and ubiquitination (isopeptide bond formation), and the protein undergoes alternative splicing. Chromosomal rearrangements involving PATZ1 are associated with proto-oncogenic activity.
• The molecular weight of PATZ1 is approximately 74 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 250–350 of human PATZ1. Given high sequence conservation, the antibody is expected to cross-react with mouse and rat PATZ1 (as indicated by cross-reactivity data).
• For Western blotting, consider optimizing antibody dilution and incubation conditions for your specific sample type. A band near 74 kDa is expected.
• The antibody is validated for ELISA; perform titration experiments to determine the optimal working concentration for your assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, research labs, and institutes with one-stop access to high-quality IVD raw materials, technical services, and consulting—from concept to clinic. For targets like PATZ1, involved in transcription regulation and cancer, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and sourcing of rare-target raw materials to support your assay development and research needs.