Anti-PATZ1 Monoclonal Antibody for WB, ELISA - Q9HBE1

Core Product Specifications and Parameters

Biological Background: PATZ1 Function and Localization

• PATZ1 (POZ-, AT hook-, and zinc finger-containing protein 1) is a transcriptional regulator that influences multiple biological processes, including embryogenesis, cellular senescence, T-cell development, and neurogenesis. Related references: PMID:10713105, PMID:25755280, PMID:31875552
• It directly interacts with TP53/p53, inhibiting its DNA binding and transcriptional activity, thereby playing a role in proliferation control and the DNA-damage response. Related references: PMID:10713105, PMID:25755280, PMID:31875552
• PATZ1 contributes to the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions. Related references: PMID:10713105, PMID:25755280, PMID:31875552
• (Microbial infection) It plays a positive role in viral cDNA synthesis.
• The protein localizes predominantly to the nucleus.
• PATZ1 is ubiquitously expressed across human tissues.
• Key features include zinc-finger domains, BTB/POZ domain, phosphorylation, isopeptide bond formation, Ubl conjugation, alternative splicing, and it is considered a proto-oncogene associated with chromosomal rearrangements in sarcomas.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 250-350 of human PATZ1; confirm that this region is conserved in your samples if working with non-human species.
• For Western blot, expect a band around 74 kDa under standard reducing conditions; consider optimizing sample preparation to resolve possible isoforms.
• ELISA can be performed using recombinant PATZ1 protein; titrate antibody and detection conditions for your assay format.
• Validate antibody specificity in your cell or tissue system using appropriate positive and negative controls.

CamelBio: Your One-Stop Sourcing Bridge

As a trusted partner for diagnostic manufacturers, research laboratories, and institutes, CamelBio streamlines access to high-quality IVD raw materials for every stage of development. Our portfolio includes validated antibody pairs, optimized monoclonal antibodies like this anti-PATZ1 clone, bulk ancillary reagents, and specialized sourcing for rare targets. Whether you are pioneering transcriptional regulation studies, immuno-oncology assays, or T-cell research, CamelBio provides reliable supply solutions to accelerate your journey from concept to clinic.