Anti-Parvalbumin/PVALB Polyclonal Antibody for WB - P20472

Core Product Specifications and Parameters

Biological Background: Parvalbumin/PVALB Function and Localization

• Parvalbumin alpha (PVALB, also known as alpha-parvalbumin) is a calcium-binding protein encoded by the PVALB gene.
• In muscle, parvalbumin is thought to facilitate relaxation after contraction by buffering intracellular calcium; it binds two calcium ions (PubMed:15122922, PubMed:39584689). Related references: PMID:15122922 PMID:39584689
• PVALB is predominantly expressed in muscle tissues.
• Post-translational modifications include acetylation and phosphorylation.
• The protein has a molecular weight of approximately 12 kDa and its three-dimensional structure has been determined.
• PVALB has been directly sequenced and serves as a proteomic reference protein.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–110) of human PVALB; verify specificity in your experimental system.
• For Western blotting, the predicted molecular weight is 12 kDa; consider using a 15% SDS-PAGE gel and optimized transfer conditions for low-molecular-weight proteins.
• In immunofluorescence and immunohistochemistry applications, validate the antibody in relevant muscle tissue samples, where PVALB is highly expressed.
• Cross-reactivity with mouse and rat is expected; include species-appropriate positive and negative controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research laboratories by offering a comprehensive portfolio of IVD raw materials, including validated antibodies like this anti-PVALB polyclonal antibody for muscle biology and calcium signaling studies. Our one-stop sourcing capabilities span antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target raw material supply, streamlining your journey from concept to clinic.