Anti-P2RY11 Rabbit Polyclonal Antibody for WB, ELISA - Q96G91

Core Product Specifications and Parameters

Biological Background: P2Y purinoceptor 11 Function and Localization

• P2Y purinoceptor 11 (P2RY11) is a member of the P2Y family of G protein-coupled receptors (GPCRs) that respond to extracellular nucleotides.
• It functions as a receptor for ATP and ADP, coupling to G proteins that activate both the phosphatidylinositol-calcium second messenger system and the adenylyl cyclase pathway.
• Unlike some other P2Y receptors, P2RY11 is not activated by UTP or UDP, demonstrating ligand selectivity.
• The receptor is localized at the cell membrane, consistent with its role in transducing extracellular nucleotide signals.
• P2RY11 is classified as a multi-pass transmembrane protein and contains structural features typical of GPCRs, including disulfide bonds and glycosylation sites.
• Tissue expression profiling indicates highest levels in liver and spleen, suggesting roles in hepatic and immune functions.

Experimental Guidance and Technical Tips

• The immunogen used to generate this antibody is a synthetic peptide corresponding to the C-terminal region (amino acids 300–379) of human P2RY11, which may contribute to epitope specificity.
• For Western blot (WB), consider using appropriate membrane protein extraction protocols and include positive controls from tissues such as liver or spleen, where P2RY11 is highly expressed.
• When performing ELISA, validate the antibody with the immunizing peptide or recombinant protein to confirm binding specificity.
• The antibody’s cross-reactivity with mouse and rat P2RY11 should be verified in the relevant sample systems if these species are critical for your experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers streamlined access to a comprehensive portfolio of IVD raw materials, including validated polyclonal antibodies like this anti-P2RY11 product for GPCR signaling research. As a dedicated sourcing partner for diagnostic manufacturers and laboratories, we supply optimized antibody pairs, monoclonal and polyclonal antibodies, bulk ancillary reagents, and can source rare-target raw materials to accelerate your assay development from concept to clinic.