Anti-P2RY11 Rabbit Polyclonal Antibody for IF/ICC and ELISA - Q96G91

Core Product Specifications and Parameters

Biological Background: P2RY11 Function and Localization

• P2Y purinoceptor 11 (P2Y11) is a G protein-coupled receptor encoded by the P2RY11 gene, belonging to the P2Y purinergic receptor family.
• The receptor specifically responds to extracellular ATP and ADP, coupling to G proteins to stimulate both phosphatidylinositol-calcium and adenylyl cyclase signaling pathways.
• P2Y11 is not activated by uridine nucleotides such as UTP or UDP, demonstrating selective ligand recognition.
• The protein localizes to the cell membrane and is predicted to contain seven transmembrane domains, along with a disulfide bond and glycosylation sites.
• Tissue expression profiling reveals the highest levels in the liver and spleen, suggesting roles in immune and metabolic processes.

Experimental Guidance and Technical Tips

• For immunofluorescence/ICC, fix and permeabilize cells appropriately to detect the membrane-bound receptor; consider optimizing permeabilization conditions.
• The immunogen sequence (aa 1-100) corresponds to the extracellular N-terminal region; ensure the antibody recognizes the native conformation if used for live-cell staining.
• For ELISA applications, use appropriate peptide or protein standards; validate with positive and negative controls.
• Confirm specificity by testing in human and mouse cell lines or tissues with known expression (e.g., liver, spleen).

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for diagnostic manufacturers, labs, and research institutes, offering one-stop access to IVD raw materials. This anti-P2RY11 antibody supports research into purinergic signaling and GPCR biology. We can supply validated antibody pairs, optimized polyclonal antibodies, bulk ancillary reagents, and assist with rare-target raw material sourcing to streamline your diagnostic development pipeline.