Anti-P23/PTGES3 Rabbit Polyclonal Antibody for IHC-P, ELISA - Q15185

Core Product Specifications and Parameters

Biological Background: P23/PTGES3 Function and Localization

• Prostaglandin E synthase 3 (PTGES3), also known as cytosolic prostaglandin E2 synthase (cPGES), Hsp90 co-chaperone, progesterone receptor complex p23, and telomerase-binding protein p23.
• Catalyzes the oxidoreduction of PGH2 to PGE2 in the cytosol, a key step in prostaglandin biosynthesis. (PubMed:10922363) Related references: PMID:10922363
• Acts as a molecular chaperone, localizing to genomic response elements in a hormone-dependent manner, and disrupts receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes. (PubMed:11274138, PubMed:12077419) Related references: PMID:11274138 PMID:12077419
• Facilitates HIF alpha protein hydroxylation by recruiting EGLN1/PHD2 to the HSP90 pathway. (PubMed:24711448) Related references: PMID:24711448
• Primarily located in the cytoplasm.
• Subject to acetylation, phosphorylation, and alternative splicing; involved in lipid biosynthesis and metabolism.
• Predicted molecular weight of 18.7 kDa, observed at ~19 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1-110 of human P23/PTGES3 (NP_006592.3), covering the N-terminal region. This design suggests the antibody may recognize full-length protein; consider verifying isoform specificity if splice variants are a concern.
• Suited for IHC-P and ELISA applications. For IHC-P, optimize antigen retrieval and antibody dilution using positive control tissues known to express PTGES3, such as placenta or cancer tissues.
• Demonstrates cross-reactivity with mouse and rat, allowing multispecies studies; validate in your specific experimental context.
• As a polyclonal antibody, performance may vary between lots; we recommend validating each new lot in your assay system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive portfolio of IVD raw materials, including this P23/PTGES3 polyclonal antibody, to support your diagnostic and research needs in prostaglandin metabolism and molecular chaperone studies. Beyond antibodies, we provide validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets, helping you move from concept to clinic efficiently. Partner with us to streamline your supply chain with reliable, high-quality raw materials.