Anti-Olig1 Monoclonal Antibody for WB, ELISA - Q8TAK6

Core Product Specifications and Parameters

Biological Background: Olig1 Function and Localization

• Olig1 (oligodendrocyte transcription factor 1), also designated BHLHB6 and BHLHE21, is a basic helix‑loop‑helix (bHLH) transcription factor encoded by the OLIG1 gene.
• In concert with OLIG2, it directs cortical gliogenesis by promoting oligodendrocyte precursor cell formation while repressing olfactory bulb interneuron progenitors through transcriptional silencing of GSX2 enhancers.
• Together with OLIG2, Olig1 establishes the pMN progenitor domain of the embryonic neural tube, a critical source of motor neurons and oligodendrocytes.
• The protein resides in the nucleus, where it binds DNA to regulate developmental gene expression programs.
• Olig1 is predominantly expressed in brain oligodendrocytes and is strongly detected in oligodendrogliomas; its expression in astrocytomas and glioblastomas is more variable.
• Annotated keywords include developmental protein, DNA‑binding, transcription regulation, and Ubl conjugation, reflecting its regulatory roles and potential for post‑translational modification.

Experimental Guidance and Technical Tips

• The antibody was raised against a synthetic peptide spanning residues 172‑271 of human Olig1, a region designed to confer target specificity; verify recognition of endogenous Olig1 in your model.
• By Western blot, Olig1 migrates at approximately 28 kDa under standard reducing conditions; optimize loading amounts and antibody dilution for your sample type.
• This antibody has been tested in ELISA and WB with cross‑reactivity to human, mouse, and rat Olig1. Independent validation in your experimental system is advisable.
• When analyzing brain tissue or oligodendrocyte‑lineage cells, include appropriate positive and negative controls to account for variable Olig1 expression.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides IVD manufacturers and research laboratories with a reliable one‑stop channel for high‑quality raw materials and technical support. This anti‑Olig1 monoclonal antibody is a core offering for neuroscience and glioma research, complemented by our capacity to supply validated antibody pairs, bulk auxiliary reagents, and customized sourcing for rare targets. We help streamline your workflow from early discovery to diagnostic application with integrated solutions.