Anti-ODC1 Rabbit Monoclonal Antibody for WB, ELISA - P11926

Core Product Specifications and Parameters

Biological Background: ODC1 Function and Localization

• Ornithine decarboxylase (ODC1) is the first and rate-limiting enzyme in polyamine biosynthesis, converting ornithine to putrescine, a precursor for spermidine and spermine.
• Polyamines play essential roles in cell proliferation, DNA replication, and apoptosis, linking ODC1 activity to fundamental cellular processes.
• ODC1 is a pyridoxal phosphate-dependent decarboxylase belonging to the lyase class, and is regulated by phosphorylation and S-nitrosylation.
• Mutations in ODC1 are associated with human diseases, including hypotrichosis (hair loss), as indicated by the disease variant keyword.
• The protein has a molecular weight of approximately 51 kDa and is widely studied as a target in cancer and proliferative disorders.

Experimental Guidance and Technical Tips

• For Western blot (WB), this antibody may detect a band at approximately 51 kDa corresponding to endogenous ODC1 in human cell lysates. Optimize loading and exposure due to potentially low expression levels.
• For ELISA, consider using the immunogen peptide or recombinant ODC1 protein as coating antigen; validate antibody dilution and detection conditions in your system.
• Since the immunogen is a synthetic peptide from the N-terminus (aa 1-100), the epitope is likely in this region. Confirm reactivity with full-length ODC1 and relevant isoforms.
• Cross-reactivity with other species has not been reported; validate in the species of interest before use.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, laboratories, and research institutes comprehensive access to IVD raw materials, including validated ODC1 antibodies for polyamine biosynthesis research. We provide optimized monoclonal antibodies, bulk ancillary reagents, and rare target sourcing solutions to support your assay development from concept to clinic. Partner with CamelBio to streamline your procurement and accelerate your diagnostic projects.