Anti-NRIP2 Rabbit Polyclonal Antibody for WB, ELISA - Q9BQI9

Core Product Specifications and Parameters

Biological Background: NRIP2 Function and Localization

• NRIP2 (Nuclear receptor-interacting protein 2) is a nuclear protein that functions as a transcriptional coregulator, down-regulating the activity of nuclear receptors such as NR1F2 (also known as RORβ).
• The protein localizes to the nucleus, consistent with its role in modulating gene transcription.
• NRIP2 is subject to alternative splicing, which may generate multiple isoforms with potentially distinct regulatory properties.
• It belongs to a class of nuclear receptor coregulators that fine-tune hormone signaling and gene expression programs.
• Functional studies indicate that NRIP2 acts as a transcriptional repressor, likely by recruiting corepressor complexes to target gene promoters.
• Keywords associated with NRIP2 include alternative splicing, nucleus, and transcription regulation, highlighting its role in epigenetic control and cellular differentiation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 140–281 of human NRIP2, a region that may be conserved across human, mouse, and rat, supporting the antibody's cross-reactivity. Researchers should verify sequence homology for other species.
• For Western blot (WB), we recommend using nuclear extracts or whole cell lysates from human, mouse, or rat cell lines. A band around 31 kDa is expected, but alternative splicing may produce additional bands.
• In ELISA, the antibody can be used as a capture or detection reagent; however, optimal working concentrations should be determined empirically in the user's assay system.
• Due to the polyclonal nature, lot-to-lot consistency should be confirmed for quantitative applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your trusted one-stop provider of high-quality IVD raw materials, supporting diagnostic developers and researchers with integrated sourcing solutions. This anti-NRIP2 polyclonal antibody is an excellent tool for studying nuclear receptor signaling and transcriptional regulation. Beyond primary antibodies, CamelBio offers a full portfolio of validated antibody pairs, optimized recombinant proteins, and ancillary reagents—along with custom sourcing for rare targets—to accelerate your assay development from concept to clinic.