Anti-NRF1 Rabbit Monoclonal Antibody for WB, IHC-P, IP, ELISA, ChIP, CUT&Tag - Q16656

Core Product Specifications and Parameters

Biological Background: NRF1 Function and Localization

• NRF1 (Nuclear respiratory factor 1), also referred to as Alpha-pal, is a human transcription factor encoded by the NRF1 gene.
• It activates the expression of the EIF2S1 (EIF2-alpha) gene and integrates transcriptional modulation of metabolic genes with cellular growth and development.
• NRF1 is essential for the expression of nuclear genes involved in mitochondrial respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
• The protein localizes to the nucleus, consistent with its role as a transcriptional regulator.
• NRF1 is ubiquitously expressed, with the highest levels detected in skeletal muscle.
• Key features include DNA-binding activity, phosphorylation, and involvement in transcription regulation, as highlighted by multiple proteomics and structural studies.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide spanning amino acids 300-400 of human NRF1 (UniProt Q16656); verify reactivity in your specific sample system.
• This antibody is designed for multiple applications, including WB, IHC-P, IP, ELISA, ChIP, and CUT&Tag. Each assay may require individual optimization.
• Reported cross-reactivity with mouse and rat suggests suitability for rodent models; confirm specificity in your experimental setup.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated IVD raw-material partner, offering comprehensive support from concept to clinic. This NRF1 monoclonal antibody is ideal for studies in transcriptional regulation and mitochondrial biology. Our sourcing capabilities include validated antibody pairs, optimized monoclonals, bulk reagents, and rare-target raw materials to accelerate your diagnostic and research workflows.