Anti-NLRP11 Rabbit Polyclonal Antibody for WB, ELISA - P59045

Core Product Specifications and Parameters

Biological Background: NLRP11 Function and Localization

• NLRP11 is a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, also known as NACHT, LRR and PYD domains-containing protein 11.
• It contains an N-terminal pyrin domain (PYD), a central NACHT domain (predicted ATP-binding), and C-terminal leucine-rich repeats (LRRs), characteristic of NLR family proteins.
• The protein is involved in inflammatory responses, likely playing a role in innate immunity and inflammasome regulation.
• Alternative splicing generates multiple transcript variants, indicating potential isoform diversity.
• The predicted molecular weight of the full-length protein is approximately 118 kDa (117,779 Da).

Experimental Guidance and Technical Tips

• This antibody was raised against a recombinant immunogen corresponding to amino acids 420-600 of human NLRP11; thus, it is expected to recognize epitopes within this region.
• For Western blot applications, consider using human-derived cell or tissue lysates and validate detection of a band near 118 kDa, with appropriate loading controls.
• In ELISA, confirm specificity by coating the recombinant immunogen or cell-expressed protein, and titrate the antibody to determine optimal working concentration.
• Since the antibody is a rabbit polyclonal, it may detect multiple isoforms; validate in the relevant experimental system and consider the possibility of cross-reactivity with other NLR family members.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with a comprehensive one-stop sourcing solution for IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For inflammation and innate immunity research involving NLRP11, our platform accelerates access to rare-target raw materials like this antibody, supporting your transition from concept to clinic with reliable supply and technical guidance.