Anti-Neuroplastin (NPTN) Rabbit Polyclonal Antibody for WB and ELISA - Q9Y639

Core Product Specifications and Parameters

Biological Background: Neuroplastin Function and Localization

• Neuroplastin (NPTN) is a transmembrane protein also known as stromal cell-derived receptor 1 (SDR-1).
• Functions as an accessory subunit of plasma membrane Ca2+ ATPases, stabilizing ATP2B2 and chaperoning ATP2B1 to enhance its activity. Related references: PMID:30190470
• Acts as a cell adhesion molecule involved in hippocampal long-term potentiation via p38MAPK activation and neurite outgrowth through FGFR1 signaling (by similarity).
• Plays a role in synaptic plasticity and promotes the cell membrane localization of XKR8. Related references: PMID:27503893
• Localizes to the cell membrane and postsynaptic density.
• Isoform 1 is ubiquitously expressed; isoform 2 is specifically expressed in brain cortex and cerebellum.
• Contains immunoglobulin domains, disulfide bonds, and glycosylation sites; classified under alternative splicing, neurogenesis, and cell adhesion keywords.

Experimental Guidance and Technical Tips

• For Western blotting, anticipate a band at approximately 44 kDa in lysates from human, mouse, or rat tissues. Validate detection in your specific sample system.
• When using in ELISA, optimize coating conditions and antibody dilution for your antigen and assay format.
• Consider this antibody for studying synaptic plasticity and cell adhesion mechanisms; appropriate functional assays should be employed as downstream validation.

CamelBio: Your One-Stop Sourcing Bridge

• As a one-stop IVD raw-material sourcing partner, CamelBio provides validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target sourcing to support your diagnostic and research developments. The Neuroplastin polyclonal antibody is part of our extensive catalog for studying cell adhesion and synaptic plasticity. Our team assists from concept to clinic, ensuring seamless procurement for your projects.