Anti-NCR1 Rabbit Polyclonal Antibody for WB, ELISA - O76036

Core Product Specifications and Parameters

Biological Background: NCR1 Function and Localization

• Natural cytotoxicity triggering receptor 1 (NCR1), also known as NKp46 or CD335, is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily.
• It functions as an activating receptor that enhances the cytotoxicity of natural killer (NK) cells, contributing to efficient tumor cell lysis.
• NCR1 is selectively expressed on both resting and activated NK cells, where it plays a key role in innate immune surveillance against malignancies.
• The protein contains immunoglobulin-like domains and a transmembrane helix, anchoring it to the cell membrane to mediate activation signals.
• Alternative splicing produces multiple isoforms, and post-translational modifications include disulfide bond formation and glycosylation, as indicated by proteomics identification.
• This receptor is a critical component of the NK cell receptor repertoire and is studied in immuno-oncology for its potential in immunotherapeutic targeting.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 151–303 of human NCR1, covering a portion of the extracellular domain; consider this region when assessing epitope accessibility in native and denaturing conditions.
• This polyclonal antibody is recommended for WB and ELISA; optimal dilutions should be determined empirically by the end user.
• Cross-reactivity with mouse and rat NCR1 is reported; validate detection in the relevant sample system, as sequence homology may influence signal intensity.
• For WB, the expected molecular weight is ~34 kDa; ensure adequate protein loading and consider glycosylation which may shift the observed band.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized polyclonal antibodies, and ancillary reagents, tailored to support your NK cell and immuno-oncology research. As a B2B sourcing partner, we streamline procurement from concept to clinic—covering bulk supply, rare target sourcing, and technical consultation. Whether you need this anti-NCR1 antibody or custom solutions for diagnostic development, our team is ready to bridge your supply chain needs efficiently.