Anti-NBEAL2 Polyclonal Antibody for WB, ELISA - Q6ZNJ1

Core Product Specifications and Parameters

Biological Background: NBEAL2 Function and Localization

• Neurobeachin-like protein 2 (NBEAL2), also known as KIAA0540, is encoded by the NBEAL2 gene and belongs to the beige and Chediak-Higashi (BEACH) domain-containing protein family.
• NBEAL2 likely functions in thrombopoiesis, particularly in the development or secretion of platelet alpha-granules, which store growth factors critical for platelet biogenesis and hemostasis.
• The protein localizes to the endoplasmic reticulum, suggesting a role in protein trafficking or granule biogenesis within megakaryocytes.
• NBEAL2 is specifically expressed in megakaryocytes, the bone marrow cells that produce platelets, consistent with its role in platelet formation.
• The protein contains WD repeats, which are involved in protein-protein interactions, and is classified as a phosphoprotein, indicating regulation by phosphorylation.
• Alternative splicing generates multiple isoforms, which may contribute to functional diversity or tissue-specific regulation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a recombinant fragment spanning amino acids 1800–2100 of human NBEAL2 (NP_055990.1), targeting the C-terminal region; this may help detect full-length NBEAL2 (~303 kDa) in Western blotting.
• For WB, use reducing conditions and appropriate high-molecular-weight protein markers; validate band specificity in megakaryocyte or platelet lysates.
• For ELISA, consider optimizing antigen coating conditions and antibody titration for human sample matrices.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw material procurement by providing high-quality antibodies like this anti-NBEAL2 polyclonal antibody, ideal for hematology and platelet biology research. With capabilities spanning validated antibody pairs, bulk reagent supply, and rare target sourcing, we support diagnostic manufacturers and labs from early-stage development to scalable production.