Anti-NAPB Rabbit Polyclonal Antibody for WB, ELISA - Q9H115

Core Product Specifications and Parameters

Biological Background: NAPB Function and Localization

• Beta-soluble NSF attachment protein (NAPB, also known as SNAP-beta) is a member of the soluble NSF attachment protein (SNAP) family, which mediates membrane fusion events by modulating the ATPase activity of N-ethylmaleimide-sensitive factor (NSF).
• NAPB is essential for vesicular transport between the endoplasmic reticulum and the Golgi apparatus, playing a critical role in the secretory pathway.
• This protein localizes to membrane compartments, consistent with its function in intracellular trafficking.
• Alternative splicing produces multiple isoforms, contributing to functional diversity.
• Mutations in NAPB are linked to developmental and epileptic encephalopathy 107 (DEE107) and intellectual disability, highlighting its importance in neurological function.
• The protein is also identified by proteomics and is classified under the keyword category "Protein transport".

Experimental Guidance and Technical Tips

• The immunogen was designed using the N-terminal region (amino acids 1-50) of human NAPB, which may confer target specificity. For cross-reactivity with mouse and rat, consider sequence alignment verification.
• In Western blot (WB), a band around 34 kDa is expected. Optimize blocking and antibody dilution based on sample type and expression levels.
• ELISA performance may vary with plate type and antigen presentation; include appropriate controls.
• Although cross-reactivity is indicated for human, mouse, and rat, validate in the relevant sample system and consider species-specific post-translational modifications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and laboratories with a reliable supply of this anti-NAPB polyclonal antibody, supporting research into ER-Golgi vesicular trafficking and neurodevelopmental disorders. Beyond individual reagents, our portfolio includes validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target sourcing capabilities—offering a convenient, integrated pathway from research to diagnostic development. We help you move faster from concept to clinic.