Anti-NACC1 Rabbit Polyclonal Antibody for WB, ELISA - Q96RE7

Core Product Specifications and Parameters

Biological Background: NACC1 Function and Localization

• Nucleus accumbens-associated protein 1 (NACC1), also known as BTB/POZ domain-containing protein 14B (BTBD14B) or NAC1, is a transcriptional repressor.
• It functions as a transcriptional corepressor in neuronal cells by recruiting HDAC3 and HDAC4, thereby regulating gene expression.
• NACC1 enhances tumor progression, proliferation, and survival, partly through repressing the transcriptional activity of GADD45GIP1.
• It is required for relocating the proteasome from the nucleus to the cytoplasm and dendritic spines.
• Subcellular localization includes both the nucleus and cytoplasm.
• Overexpressed in ovarian serous carcinomas and other carcinomas, its expression levels correlate with tumor recurrence and chemotherapy resistance.
• Keywords indicate involvement in disease variants (epilepsy, intellectual disability) and post-translational modifications such as phosphorylation and ubiquitination.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 170-340 of human NACC1; for applications targeting this region, verify epitope accessibility in your sample type.
• For Western blotting, validate a band at approximately 57 kDa in human or mouse lysates and include appropriate controls to confirm specificity.
• In ELISA, consider optimizing coating conditions and antibody concentrations; confirm cross-reactivity with human and mouse NACC1 in your assay.
• As a polyclonal antibody, lot-to-lot variability may occur; test each new batch in preliminary experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for diagnostic manufacturers and research institutes, offering a wide range of IVD raw materials from concept to clinic. For NACC1 research, we provide validated antibodies such as this anti-NACC1 polyclonal antibody, along with ancillary reagents and bulk ordering options. Explore our catalog for matched antibody pairs, recombinant proteins, and custom services to accelerate your assay development.