Anti-NAA40 Polyclonal Antibody for WB, ELISA - Q86UY6

Core Product Specifications and Parameters

Biological Background: NAA40 Function and Localization

• N-alpha-acetyltransferase 40 (NAA40), also known as NatD, NAT11, PATT1, and hNatD, is a member of the N-acetyltransferase family that specifically acetylates the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). Related references: PMID:21935442 PMID:25619998
• It recognizes the 'Ser-Gly-Arg-Gly' sequence at the N-terminus of histones H4 and H2A, distinguishing it from other N-alpha-acetyltransferases.
• NAA40 acts as a negative regulator of apoptosis (PubMed:26666750). Related references: PMID:26666750
• May play a role in hepatic lipid metabolism (by similarity).
• The protein localizes to both the cytoplasm and nucleus.
• Widely expressed at the protein level, with highest expression in liver and lowest in brain.
• Keywords from UniProt include acyltransferase, alternative splicing, lipoprotein, myristate, and transferase, suggesting post-translational modifications and isoform diversity.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 1-237 of human NAA40, covering the full-length protein; therefore, the antibody may detect the native protein in Western blot under denaturing conditions at the predicted molecular weight of 27 kDa.
• For ELISA applications, consider standard indirect ELISA protocols with appropriate secondary antibody detection.
• Since NAA40 is expressed in multiple tissues with higher abundance in liver, include liver cell lysates as positive controls and validate in your relevant sample system.
• Although cross-reactivity is listed as human, homology with other species is unknown; verify cross-reactivity if needed.
• Optimize antibody dilution and incubation conditions empirically, as specific recommendations are not provided.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, supporting assays targeting epigenetic modifiers like NAA40. Our supply capabilities include validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to accelerate your assay development. Contact us to discuss your specific requirements for histone modification research tools.