Anti-MYT1 Rabbit Polyclonal Antibody for WB, ELISA - Q01538

Core Product Specifications and Parameters

Biological Background: MYT1 Function and Localization

• MYT1 (Myelin transcription factor 1) is a zinc finger transcription factor encoded by the MYT1 gene, playing a pivotal role in central nervous system development, particularly in oligodendrocyte lineage progression.
• It binds specifically to the promoter regions of genes encoding proteolipid proteins, thereby regulating myelin gene transcription and contributing to myelination.
• MYT1 is predominantly localized in the nucleus, consistent with its function as a transcriptional regulator.
• The protein exhibits highest expression in neural progenitors and oligodendrocyte progenitor cells, with levels declining as cells differentiate into mature oligodendrocytes, indicating a role in maintaining the progenitor state and controlling the timing of terminal differentiation.
• MYT1 contains multiple C2H2-type zinc finger domains, which mediate its DNA-binding activity and transcriptional regulation.
• Alternative splicing generates multiple protein isoforms, some of which may have distinct tissue distributions or functional roles.
• Keywords associated with MYT1 include developmental protein, differentiation, neurogenesis, and transcription regulation, underscoring its importance in neural development.

Experimental Guidance and Technical Tips

• The immunogen for this antibody corresponds to amino acids 650–820 of human MYT1 (NP_004526.1). This region may recognize multiple isoforms; consider verifying isoform specificity if needed.
• For Western blot, a band at approximately 122 kDa is expected. Optimize primary antibody dilution and incubation conditions based on your sample type and detection system.
• Validated applications include WB and ELISA. Cross-reactivity has been reported with human, mouse, and rat samples; validation in your specific experimental context is recommended.
• Consider appropriate blocking and washing steps to minimize non-specific binding, especially when working with tissues rich in myelin or neural proteins.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves diagnostic manufacturers, laboratories, and research institutes as a comprehensive IVD raw-material partner, supporting every stage from concept to clinic. For targets like MYT1, which are central to neuroscience and developmental biology research, we offer validated antibody pairs, optimized polyclonal antibodies, bulk ancillary reagents, and bespoke sourcing for rare raw materials. Connect with us to streamline your supply chain and advance your assay development projects.