Anti-MXD1 Rabbit Polyclonal Antibody (WB, ELISA) - Q05195

Core Product Specifications and Parameters

Biological Background: MXD1 Function and Localization

• MXD1 (Max dimerization protein 1, also known as MAD) is a component of a transcriptional repressor complex together with MAX. Related references: PMID:8425218
• The MXD1-MAX complex binds to the core DNA sequence 5'-CAC[GA]TG-3' (E-box) and antagonizes MYC transcriptional activity by competing for MAX binding. Related references: PMID:8425218
• It binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. Related references: PMID:12837246
• MXD1 is localized in the nucleus, consistent with its DNA-binding and transcriptional regulatory functions.
• The protein undergoes alternative splicing and is subject to ubiquitin-like conjugation (ubl conjugation), as indicated by keywords.
• It belongs to the reference proteome and has a 3D-structure available.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a synthetic peptide within amino acids 100-200 of human MXD1 (NP_002348.1); antibodies may recognize multiple isoforms due to alternative splicing.
• For Western blotting, detect a band around 25 kDa; consider titration to optimize signal-to-noise ratio and validate species reactivity in the target sample system.
• In ELISA applications, confirm binding to the target antigen and evaluate cross-reactivity with human and rat species; consider using recombinant proteins as standards.
• As the antibody is polyclonal, lot-to-lot variation may occur; validate each new lot for critical experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your comprehensive partner for IVD raw-material procurement, providing ready access to validated antibody pairs, optimized polyclonal antibodies like this anti-MXD1 reagent, and bulk ancillary materials. We support research and diagnostic development in transcriptional regulation, cancer biology, and telomerase studies with one-stop sourcing from concept to clinic. Whether you need rare target raw materials or scalable production, CamelBio bridges your supply needs efficiently.