Anti-MUC6 Polyclonal Antibody for WB, ELISA - Q6W4X9

Core Product Specifications and Parameters

Biological Background: MUC6 Function and Localization

• MUC6 encodes mucin-6, also known as gastric mucin-6, a large secreted glycoprotein.
• Plays a critical role in the protective mucus layer of the gastrointestinal tract, providing cytoprotection to epithelial surfaces.
• Modulates mucus composition in response to acid secretion, bacteria, and noxious agents.
• Used as a tumor marker in a variety of cancers and may function in epithelial organogenesis.
• Secreted and expressed specifically in gastric antrum and body mucosa, duodenal Brunner's glands, gallbladder, seminal vesicle, and pancreatic ducts.
• Overexpressed in Helicobacter pylori-infected gastric epithelium.
• Characterized by disulfide bonds, repetitive sequences, and extensive glycosylation.

Experimental Guidance and Technical Tips

• The immunogen targets the N-terminal region (aa 33-298) of human MUC6; verify specificity in your target tissue.
• For Western blot, anticipate a high molecular weight band (~257 kDa) and use appropriate gel and transfer conditions.
• Cross-reactivity with mouse MUC6 makes it suitable for mouse model studies; validation in mouse samples is recommended.
• Optimal antibody dilution and incubation times should be empirically determined for your specific assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with one-stop access to IVD raw materials, including this polyclonal antibody to MUC6—a valuable tool for gastrointestinal and cancer biology research. We support your entire workflow with validated antibody pairs, optimized monoclonals and polyclonals, bulk ancillary reagents, and sourcing of rare targets. From concept to clinic, CamelBio helps bridge your IVD development needs efficiently.