Anti-Mu Opioid Receptor (MOR) Rabbit Polyclonal Antibody for WB, IF-P, IHC-P, ELISA - P35372

Core Product Specifications and Parameters

Biological Background: Mu-type opioid receptor Function and Localization

• Mu-type opioid receptor (MOR), encoded by the OPRM1 gene (also known as MOR1, MOP, hMOP), is a class A G protein-coupled receptor (GPCR) that mediates the pharmacological effects of opioids.
• It functions as a high-affinity receptor for endogenous opioids (beta-endorphin, endomorphin) and natural/synthetic opioids including morphine, DAMGO, fentanyl, and methadone. Related references: PMID:10529478, PMID:12589820, PMID:7891175, PMID:10836142
• Agonist binding triggers coupling to pertussis toxin-sensitive G proteins (Gi/o), leading to inhibition of adenylate cyclase, modulation of calcium and potassium channels, and activation of MAPK and PI3K pathways. Related references: PMID:7905839, PMID:12068084
• Receptor signaling is tightly regulated: phosphorylation by GRKs promotes beta-arrestin recruitment, resulting in desensitization, clathrin-mediated endocytosis, and subsequent recycling or degradation.
• MOR localizes primarily to the cell membrane but is also found in cell projections (axon, dendrite), endosomes, and cytoplasm, reflecting its dynamic trafficking during signaling.
• It is predominantly expressed in the brain; specific isoforms (16 and 17) are detected in brain tissue.
• Post-translational modifications include N-glycosylation, palmitoylation, and phosphorylation, which influence receptor stability, trafficking, and signaling efficacy.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (aa 354–388) of human MOR, suggesting the antibody likely recognizes full-length receptor and isoforms containing this epitope; validate in your specific sample system.
• For Western blot (WB), an expected band around 45 kDa may be observed; consider using appropriate positive controls and molecular weight markers.
• When performing IHC-P, antigen retrieval may be required; brain tissue sections serve as a positive control given high MOR expression.
• The antibody cross-reacts with mouse and rat MOR, making it suitable for studies in rodent models; however, confirm reactivity under your experimental conditions.
• For ELISA, titrate antibody concentration and validate using recombinant protein or cell lysates expressing MOR.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers this anti-MOR polyclonal antibody as part of a comprehensive portfolio of IVD raw materials for opioid receptor research and diagnostic development. As a one-stop sourcing partner, we provide validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets, helping you streamline the journey from concept to clinic.