Anti-MTX2 Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - O75431

Core Product Specifications and Parameters

Biological Background: MTX2 Function and Localization

• Metaxin-2 (MTX2), also known as mitochondrial outer membrane import complex protein 2, is a key component of the mitochondrial protein import machinery.
• It functions in the transport of precursor proteins from the cytosol into the mitochondrion, facilitating their translocation across the outer membrane.
• MTX2 localizes to the mitochondrial outer membrane, where it likely interacts with other import receptors and translocases.
• The protein undergoes alternative splicing, producing multiple isoforms that may have distinct functional roles.
• Post-translational modifications include acetylation, which could regulate its activity or stability.
• MTX2 is associated with osteoporosis, as indicated by disease-association keywords, suggesting a potential link between mitochondrial function and bone metabolism.
• It is a reference proteome component and has been identified in proteomics studies, confirming its broad expression.

Experimental Guidance and Technical Tips

• The immunogen was designed against the full-length (aa 1-263) of human MTX2, so the antibody likely recognizes the native protein in various applications.
• For Western blotting, the expected band is approximately 30 kDa (predicted MW 29.8 kDa). Consider using a mitochondrial marker or GAPDH as a loading control.
• In immunohistochemistry (IHC-P), validate the antibody on tissues with high mitochondrial content, such as heart, skeletal muscle, or kidney.
• Since the antibody cross-reacts with mouse and rat, it can be used in comparative studies across these species.
• For ELISA applications, pair with a suitable capture antibody or use as a detection reagent; optimize coating and incubation conditions experimentally.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes with streamlined access to IVD raw materials, supporting projects from concept to clinic. Our portfolio includes validated antibody pairs, optimized monoclonal/polyclonal antibodies, and ancillary reagents for mitochondrial research and assay development. Contact us for bulk orders or assistance in sourcing rare targets like mitochondrial import proteins.