Anti-MTUS1 Polyclonal Antibody for WB, ELISA - Q9ULD2

Core Product Specifications and Parameters

Biological Background: MTUS1 Function and Localization

• Protein identity: MTUS1 (Microtubule-associated tumor suppressor 1) is also known as AT2 receptor-binding protein (ATBP) or Angiotensin-II type 2 receptor-interacting protein. Multiple isoforms exist due to alternative splicing.
• Core function: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation, acting as a tumor suppressor. Isoform 1 inhibits breast cancer cell proliferation and delays mitotic progression by prolonging metaphase.
• Subcellular localization: Found in multiple compartments including mitochondrion, Golgi apparatus, cell membrane, nucleus, and cytoskeleton (centrosome, spindle). This suggests diverse roles in cell signaling and division.
• Tissue specificity: Ubiquitously expressed, with highest levels in brain. Down‑regulated in various carcinomas (ovarian, pancreas, colon, head and neck squamous cell carcinoma). Isoform 3 is the major isoform in brain, while isoform 6 is brain‑specific (cerebellum and fetal brain).
• Post‑translational modifications: Classified as a phosphoprotein, indicating regulation by phosphorylation.
• Functional associations: May be required for AGTR2 cell surface expression; together with PTPN6, induces UBE2V2 expression upon angiotensin‑II stimulation.
• Disease relevance: Linked to cancer as a tumor suppressor; alternative splicing generates isoforms with potentially distinct functions.

Experimental Guidance and Technical Tips

• The immunogen, a recombinant fusion protein covering amino acids 207‑436, includes regions potentially involved in protein‑protein interactions (e.g., with AGTR2). Consider verifying antibody specificity for your application using appropriate controls.
• For Western blot, a band corresponding to the full‑length isoform 1 is expected at ~141 kDa; however, smaller bands representing other isoforms may also be detected due to the polyclonal nature. Validate band patterns using isoform‑specific positive controls or siRNA knockdown in your sample system.
• This antibody is validated for ELISA. When developing an ELISA, consider using the recombinant immunogen as a standard and pairing with a suitable detection antibody.
• Given MTUS1's multiple subcellular localizations, ensure appropriate sample preparation (e.g., subcellular fractionation) to enrich for the target compartment if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your integrated partner for IVD raw material procurement, providing a wide range of validated antibodies, recombinant proteins, and ancillary reagents to support diagnostic development. For MTUS1‑related oncology research, we offer customizable bulk supply of polyclonal antibodies, monoclonal alternatives, and matched antibody pairs, alongside technical consultation to streamline your assay workflow from concept to clinic. Whether you need rare target reagents or optimized detection systems, CamelBio bridges the gap between discovery and commercialization.