Anti-MTTP Polyclonal Antibody for WB, ELISA - P55157

Core Product Specifications and Parameters

Biological Background: MTTP Function and Localization

• MTTP functions as a lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Related references: PMID:15897609, PMID:16478722, PMID:22236406
• It is required for the assembly and secretion of apolipoprotein B (apoB)-containing plasma lipoproteins. Related references: PMID:16478722, PMID:23475612, PMID:26224785
• MTTP may also regulate cholesteryl ester biosynthesis in lipoprotein-producing cells.
• Subcellular localization includes the endoplasmic reticulum and Golgi apparatus.
• Tissue expression is highest in liver and small intestine, with additional expression in ovary, testis, and kidney.
• Alternative splicing generates multiple isoforms; the protein contains a signal peptide and disulfide bonds, and is linked to metabolic diseases.

Experimental Guidance and Technical Tips

• For WB, a 99 kDa band corresponding to MTTP should be detectable; consider using an 8-10% SDS-PAGE gel for optimal resolution and validate specificity with appropriate controls.
• Given cross-reactivity with human, mouse, and rat, the antibody may be suitable for multi-species studies; validate performance in the relevant sample system.
• In ELISA applications, optimize coating conditions and antibody concentrations for your specific assay format.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, providing validated polyclonal and monoclonal antibodies, optimized antibody pairs, and bulk ancillary reagents to support your lipid metabolism and lipoprotein research. Whether you need MTTP antibodies for assay development or other rare targets, CamelBio streamlines procurement from concept to clinic.