Anti-MTMR9 Rabbit Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q96QG7

Core Product Specifications and Parameters

Biological Background: MTMR9 Function and Localization

• MTMR9 is an inactive myotubularin-related phosphatase adapter, encoded by the MTMR9 gene (also known as C8orf9 or MTMR8), with multiple isoforms produced by alternative splicing.
• Acts as an adapter for the lipid phosphatases MTMR6, MTMR7, and MTMR8, enhancing their catalytic activities. Related references: PMID:19038970 PMID:22647598
• Specifically increases MTMR6 activity toward phosphatidylinositol 3,5-bisphosphate and its binding to phosphorylated phosphatidylinositols, while also stabilizing MTMR6 protein levels through complex formation. Related references: PMID:19038970 PMID:22647598
• Increases MTMR8 catalytic activity toward phosphatidylinositol 3-phosphate and stabilizes MTMR8 protein levels. Related references: PMID:22647598
• Plays a role in the late stages of macropinocytosis, likely by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate at membrane ruffles. Related references: PMID:24591580
• Negatively regulates autophagy through its association with MTMR8, and suppresses DNA damage-induced apoptosis through its interaction with MTMR6. Related references: PMID:22647598 PMID:19038970
• Does not bind mono-, di-, and tri-phosphorylated phosphatidylinositols, phosphatidic acid, or phosphatidylserine. Related references: PMID:19038970
• Localizes to the cytoplasm, perinuclear region, endoplasmic reticulum, and cell projections including ruffle membranes.

Experimental Guidance and Technical Tips

• The immunogen comprises the N-terminal 250 amino acids, which may recognize multiple isoforms; verify specificity in your experimental system.
• For western blot, expect a predominant band at approximately 63 kDa; consider using appropriate positive and negative controls.
• Validate antibody reactivity in human, mouse, and rat samples; further dilution optimization may be needed for IHC-P and IF/ICC.
• For immunofluorescence applications, mild fixation and permeabilization conditions are recommended to preserve both cytosolic and membrane-associated MTMR9 pools.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, research laboratories, and institutes with one-stop access to IVD raw materials, technical services, and consulting—from concept to clinic. We offer a comprehensive portfolio of validated antibodies, bulk ancillary reagents, and rare target sourcing to support your MTMR9-related studies and assay development. Our team can also assist with custom procurement of other myotubularin-family targets and complementary reagents.