Anti-MTFP1 Rabbit Polyclonal Antibody for WB, ELISA - Q9UDX5

Core Product Specifications and Parameters

Biological Background: MTFP1 Function and Localization

• MTFP1, also known as MTP18 or mitochondrial 18 kDa protein, is a mitochondrial inner membrane protein encoded by the MTFP1 gene in humans.
• It plays a critical role in regulating mitochondrial morphology by inhibiting mitochondrial fusion.
  Related references: PMID:15155745, PMID:15985469
• MTFP1 creates a non-fusogenic lipid environment that disrupts OPA1 oligomerization, thereby blocking mitochondrial fusion.
  Related references: PMID:38851188
• This activity promotes the segregation of defective inner mitochondrial membrane domains into small MTFP1-enriched mitochondria (SMEM), which are targeted for autophagic degradation.
  Related references: PMID:38851188, PMID:41398051
• The inner mitochondrial membrane quality control process mediated by MTFP1 also helps regulate mitochondrial DNA levels.
  Related references: PMID:38851188
• MTFP1 is localized to the mitochondrial inner membrane and is characterized by alternative splicing and transmembrane domains, as annotated in UniProt.
• The predicted molecular weight of human MTFP1 is approximately 18 kDa, consistent with its alias MTP18.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the full-length human MTFP1 sequence (amino acids 1-166), suggesting the antibody may recognize native protein.
• For Western blotting, validate the antibody in relevant sample lysates from human, mouse, or rat cells expressing MTFP1; expect a band around 18 kDa under standard denaturing conditions.
• For ELISA, consider checkerboard titration with the target antigen and appropriate negative controls to determine optimal working concentrations.
• Since the antibody is polyclonal, potential batch-to-batch variation may occur; new lots should be tested in the intended assay system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with integrated access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-MTFP1 polyclonal antibody supports research into mitochondrial dynamics and fission mechanisms, and we can supply it as part of a broader suite of validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target raw material sourcing. For custom requirements or large-volume orders, our team offers tailored procurement solutions to streamline your assay development pipeline.