Anti-MTCH2 Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q9Y6C9

Core Product Specifications and Parameters

Biological Background: MTCH2 Function and Localization

• MTCH2 (Mitochondrial carrier homolog 2), also known as Met-induced mitochondrial protein (MIMP), is a multi-pass transmembrane protein localized to the mitochondrial outer membrane.
• It functions as a protein insertase that mediates the insertion of alpha-helical transmembrane proteins into the mitochondrial outer membrane, but not beta-barrel proteins. Related references: PMID:36264797
• Acts as a receptor for truncated p15 BID, playing a critical role in the intrinsic apoptosis pathway.
• Regulates hematopoietic stem cell quiescence and cycling, and is essential for the naive-to-primed interconversion of embryonic stem cells by modulating mitochondrial fusion.
• Involved in lipid homeostasis and has a regulatory role in adipocyte differentiation.
• Post-translational modifications include acetylation; classified under keywords such as Mitochondrion outer membrane, Transmembrane helix, and Transport.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 30–175 of human MTCH2, a region likely accessible in various applications; consider validating the antibody in your specific sample system and application.
• For Western blotting, a band around 33 kDa is expected; use appropriate positive controls (e.g., human or mouse cell lysates) and optimize antibody dilutions experimentally.
• In immunohistochemistry (IHC-P) and immunofluorescence (IF/ICC), fixation and permeabilization conditions may influence signal; pilot experiments are recommended.
• This polyclonal antibody may exhibit lot-to-lot variation; include appropriate controls and consider characterization in your assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw-material procurement for diagnostic manufacturers and research teams. This anti-MTCH2 antibody supports studies in mitochondrial biology, apoptosis, and stem cell regulation. Beyond this product, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and specialized sourcing for rare targets—backed by reliable supply chains and technical support from concept to clinic.