Anti-MSMB Polyclonal Antibody for WB, ELISA - P08118

Core Product Specifications and Parameters

Biological Background: Beta-microseminoprotein (MSMB) Function and Localization

• Beta-microseminoprotein (MSMB) is a secreted protein predominantly expressed in the prostate gland and found in seminal plasma.
• Alternative names include Immunoglobulin-binding factor (IGBF), Prostate secretory protein of 94 amino acids (PSP94), PSP57, and Seminal plasma beta-inhibin.
• The MSMB gene undergoes alternative splicing, producing at least two isoforms: a full-length 94‑amino acid form (PSP94) and a shorter 57‑amino acid form (PSP57).
• PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder, indicating tissue‑specific isoform distribution.
• The protein contains disulfide bonds, contributing to its structural stability.
• It has been identified through proteomics and is part of the reference proteome.
• Additional expression sites include liver, kidney, breast, penis, pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands, and fallopian tube, suggesting diverse physiological roles.
• The mature protein has a predicted molecular weight of approximately 13 kDa.

Experimental Guidance and Technical Tips

• For Western blot, anticipate a band around 13 kDa for the full‑length isoform; a lower band (~6‑7 kDa) may appear for the PSP57 isoform in kidney or bladder lysates.
• When validating in ELISA, consider using recombinant MSMB as a positive control to calibrate the assay.
• Optimize antibody dilutions based on sample type, as MSMB expression levels vary significantly across tissues.
• Cross‑reactivity has been confirmed for human samples; for other species, preliminary testing is recommended.

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