Anti-MRPL11 Rabbit Polyclonal Antibody for WB, ELISA - Q9Y3B7

Core Product Specifications and Parameters

Biological Background: MRPL11 Function and Localization

• MRPL11 encodes the mitochondrial ribosomal protein L11, a constituent of the large subunit of the mitochondrial ribosome (mitoribosome).
• It is designated as 39S ribosomal protein L11, mitochondrial (L11mt or MRP-L11) and belongs to the uL11m family of ribosomal proteins.
• The protein localizes to the mitochondrion, where it plays a role in mitochondrial protein synthesis.
• Alternative splicing of the MRPL11 transcript generates multiple variants, potentially yielding different protein isoforms.
• A transit peptide sequence directs the import of MRPL11 into the mitochondria.
• MRPL11 has been catalogued as a reference proteome component through proteomic identification studies.
• The three-dimensional structure of the mitoribosome, including MRPL11, has been resolved, contributing to understanding of its functional architecture.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–192) of human MRPL11; this design may confer specificity for mitochondrial ribosomal L11 detection.
• For Western blot applications, consider using standard denaturing conditions and validate antibody specificity with mitochondrial-enriched lysates or appropriate controls.
• In ELISA formats, pairing with a suitable detection antibody may enhance sensitivity; optimization of coating and blocking conditions is recommended.
• The antibody’s cross-reactivity with human, mouse, and rat samples makes it suitable for comparative mitochondrial studies across these species.
• Since MRPL11 is a mitochondrial protein, cellular fractionation or mitochondrial isolation can improve signal detection and reduce cytosolic background.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research laboratories with streamlined access to this MRPL11 antibody, tailored for mitochondrial ribosome studies and related applications. Beyond this catalog product, we offer one-stop sourcing of validated antibody pairs, optimized monoclonal/polyclonal reagents, bulk ancillary materials, and custom procurement for hard-to-find IVD raw materials. Whether advancing mitochondrial disease research or developing ribosomal protein assays, CamelBio bridges your concept–to–clinic supply needs with reliable B2B support.