Anti-Mouse Ly-6G/Ly-6C (Gr-1) Monoclonal Antibody () for FC - P35461 / P0CW02

Core Product Specifications and Parameters

Biological Background: Ly-6G/Ly-6C (Gr-1) Function and Localization

• Lymphocyte antigen 6G (Ly-6G), also known as Ly-6G.1, is a member of the Ly-6/uPAR protein superfamily, encoded by the Ly6g gene in mouse.
• Ly-6G is a GPI-anchored cell surface glycoprotein, as annotated with keywords: GPI-anchor, Glycoprotein, Lipoprotein, and Cell membrane.
• Subcellular localization: Ly-6G is tethered to the outer leaflet of the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor.
• Tissue specificity: It is expressed in bone marrow, consistent with its presence on myeloid lineage cells.
• The protein possesses a signal peptide for secretion, forms disulfide bonds for structural stability, and is a reference proteome member.
• The Gr-1 epitope is shared by Ly-6G and Ly-6C; this antibody recognizes both, serving as a major marker for mouse granulocytes and myeloid-derived suppressor cells.

Experimental Guidance and Technical Tips

• For flow cytometry, titrate the antibody to determine the optimal working concentration using relevant positive and negative controls.
• Use appropriate isotype controls and live/dead discrimination to gate Gr-1-positive populations accurately.
• The conjugate is bright and photostable; minimize light exposure and use standard FITC filter sets.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic developers with a comprehensive portfolio of IVD raw materials, including rigorously validated antibodies like this anti-Gr-1 monoclonal. Whether you need bulk reagents, customized antibody pairs, or support for rare target sourcing, we provide end-to-end solutions to accelerate your immunoreagent development from concept to clinic.