Anti-Mouse CD50/ICAM-3 (ICAM-5, Telencephalin) Monoclonal Antibody () for FC - Q60625

Core Product Specifications and Parameters

Biological Background: ICAM-5 (Telencephalin) Function and Localization

• ICAM-5, also known as telencephalin, is a member of the intercellular adhesion molecule (ICAM) family and an immunoglobulin superfamily protein.
• Functions as a cell adhesion molecule, serving as a ligand for the integrin ITGAL:ITGB2/LFA-1, mediating neuron–leukocyte adhesion (By similarity).
• Promotes homophilic cell adhesion that drives dendritogenesis and arborization of hippocampal neurons. Related references: PMID:22187327
• Localizes to the cell membrane, with enrichment at cellular projections including dendritic spine membranes and the uropodium.
• Expression is highly restricted to the telencephalic regions of the brain.
• Post-translationally modified; classified as a glycoprotein and phosphoprotein with disulfide bonds, and contains a single transmembrane helix.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 32–227 of mouse ICAM-5, an extracellular region; thus the antibody likely binds to the native conformation of the protein and is suitable for live-cell flow cytometry.
• For flow cytometry applications, titrate the conjugate to determine optimal staining concentration, and include appropriate isotype and fluorescence-minus-one controls.
• Given the exclusive expression of ICAM-5 in telencephalic neurons, validate the antibody on primary mouse brain cells or neuronal cultures to confirm reactivity and specificity.

CamelBio: Your One-Stop Sourcing Bridge

As a comprehensive IVD raw-material partner, CamelBio supplies high-quality antibodies like this anti-ICAM-5 monoclonal conjugate for neuroscience and cell adhesion research. We offer one-stop access to validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target sourcing to support your diagnostic and research workflows from concept to clinic.