Anti-Mouse CD161c/NK1.1 Monoclonal Antibody for FC - P27814

Core Product Specifications and Parameters

Biological Background: Killer cell lectin-like receptor subfamily B member 1C Function and Localization

• Protein identity and aliases: Killer cell lectin-like receptor subfamily B member 1C (Klrb1c) is also designated CD161c, NK1.1, NKR-P1C, and Ly-55c.
• Functional role: It acts as a stimulatory receptor on natural killer (NK) cells, enhancing their cytotoxic activity.
• Signaling and effector responses: Cross-linking of the receptor triggers Ca²⁺ mobilization and interferon-gamma production, promoting immune activation.
• Subcellular localization: The protein is anchored to the cell membrane via a transmembrane helix, exposing its extracellular C-type lectin domain.
• Post-translational modifications: It undergoes glycosylation and contains disulfide bonds, which are characteristic of lectin-like receptors.
• Isoforms: Alternative splicing generates multiple isoforms, potentially modulating receptor function.
• Expression pattern: Expression is predominantly restricted to NK cells, consistent with its role in innate immunity.
• Lectin domain feature: The receptor belongs to the C-type lectin family, suggesting involvement in carbohydrate-mediated recognition events.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular region (aa 67–223), so the antibody likely recognizes the native surface receptor; it is well suited for flow cytometry on live cells.
• For flow cytometry, titrate the antibody to determine the optimal concentration for your specific NK cell population and experimental conditions.
• Include appropriate isotype controls and consider Fc receptor blocking to minimize non-specific binding.
• Validate reactivity in your mouse strain of interest, as allelic variants may influence antibody binding.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with reliable access to IVD raw materials, technical services, and consulting—from concept to clinic. Our portfolio includes validated antibody pairs, optimized monoclonal antibodies like this anti-CD161c/NK1.1 clone, bulk ancillary reagents, and rare target sourcing. Whether you are developing immune cell profiling assays or researching NK cell biology, CamelBio streamlines your supply chain with one-stop support.