Anti-Mouse CD11c Monoclonal Antibody for FC - Q9QXH4

Core Product Specifications and Parameters

Biological Background: Integrin alpha-X Function and Localization

• Integrin alpha-X (CD11c, also known as CD11 antigen-like family member C or leukocyte adhesion receptor p150,95) is a member of the integrin family, encoded by the Itgax gene.
• It forms a heterodimer with integrin beta-2, serving as a receptor for fibrinogen by recognizing the G-P-R sequence, which facilitates cell-cell interactions during inflammatory responses.
• CD11c plays a critical role in monocyte adhesion and chemotaxis, contributing to leukocyte trafficking and immune surveillance.
• Additionally, it functions as a receptor for the erythrocyte-specific adhesion molecule ICAM4, mediating erythrophagocytosis.
• The protein localizes to the cell membrane and contains structural features such as calcium and magnesium binding sites, disulfide bonds, and multiple repeat regions typical of integrin alpha chains.
• Post-translational modifications include glycosylation, which may influence ligand binding and cellular localization.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant mouse CD11c protein; consider using native cellular samples to confirm conformation-specific binding in flow cytometry.
• Titrate the antibody to determine the optimal working concentration for your specific cell type and staining conditions.
• Verify cross-reactivity with mouse samples is as expected, and validate in the relevant tissue or cell line models for your study.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for IVD manufacturers, research laboratories, and diagnostic developers, offering validated antibodies, recombinant proteins, and ancillary reagents. This anti-mouse CD11c monoclonal antibody supports immunology research, particularly studies on inflammatory responses and cell adhesion. CamelBio’s supply chain capabilities extend to bulk orders and rare target raw-material sourcing, facilitating your workflow from concept to clinic.